887686-02-4
887686-02-4 structure
- Name: OSS_128167
- Chemical Name: OSS-128167
- CAS Number: 887686-02-4
- Molecular Formula: C19H14N2O6
- Molecular Weight: 366.32
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
- Create Date: 2018-05-21 08:00:00
- Modify Date: 2024-01-02 17:26:12
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OSS_128167 is a selective SIRT6 inhibitor with IC50s of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
| Name | OSS-128167 |
|---|
| Description | OSS_128167 is a selective SIRT6 inhibitor with IC50s of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. |
|---|---|
| Related Catalog | |
| Target |
SIRT6:89 μM (IC50) SIRT2:751 μM (IC50) SIRT1:1578 μM (IC50) |
| In Vitro | OSS_128167 is a selective SIRT6 inhibitor with IC50s of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 inhibits SIRT6 in the micromolar range, but shows promising selectivity, since its IC50 value for SIRT6 is approximately 17 times lower compare to the IC50 for SIRT1 and 9 times lower compare to SIRT2[1]. OSS_128167 (200 μM) induces chemosensitization in primary multiple myeloma (MM) cells (NCI-H929), as well as in melphalan-resistant (LR-5) and doxorubicin-resistant (Dox40) MM cell lines[2]. |
| Kinase Assay | TNF-a levels in supernatants from cells incubated for 18 h in the presence or absence of OSS_128167 (100 μM, final concentration) are measured by a commercially available ELISA kit according to the manufacturer’s instructions[1]. |
| Cell Assay | Glucose uptake is evaluated using a fluorescent D-glucose analog, 2-NBDG, in L6 cells incubated for 18 h in the presence or absence of OSS_128167 (100 μM, final concentration)[1]. |
| References |
| Molecular Formula | C19H14N2O6 |
|---|---|
| Molecular Weight | 366.32 |
| Storage condition | -20℃ |