Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: isoleucyl-lysyl-valyl-alanyl-valine
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Purity: 98.0%
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131167-89-0

131167-89-0 structure

Name: H-Ile-Lys-Val-Ala-Val-OH trifluoroacetate salt
Chemical Name: Laminin-1 peptide
CAS Number: 131167-89-0
Molecular Formula: C₂₅H₄₈N₆O₆
Molecular Weight: 528.685
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2018-05-21 08:00:00
Modify Date: 2024-01-02 16:33:53
H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways[1][2].

Name	Laminin-1 peptide
Synonyms	L-Isoleucyl-L-lysyl-L-valyl-L-alanyl-L-valine L-Valine, L-isoleucyl-L-lysyl-L-valyl-L-alanyl-

Description	H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK1 ERK2 Akt
In Vitro	H-Ile-Lys-Val-Ala-Val-OH (0-2.5 mM, 0-48 h) 诱导骨髓间充质干细胞(BMMSC)增殖和增殖细胞核抗原(PCNA)合成[2]。 H-Ile-Lys-Val-Ala-Val-OH (5 mM, 24 h) 诱导 BMMSC 细胞周期，使细胞从 G0/G1 进入 S 期并阻止它们进入 G2/M 期[2]。 H-Ile-Lys-Val-Ala-Val-OH (0-2.5 mM, 0-48 h) 通过增强 BMMSCs 中 ERK1/2 和 Akt 的磷酸化水平激活 MAPK/ERK 和 PI3K/Akt 信号通路[2]。 Cell Proliferation Assay[2] Cell Line: BMMSC Concentration: 0, 0.004, 0.02, 0.1, 0.5 and 2.5 mM Incubation Time: 0, 12, 24, 36, 48 h Result: Stimulated proliferating cell nuclear antigen (PCNA) synthesis and induced proliferation of bone marrow mesenchymal stem cell (BMMSC) in a dose- and time-dependent manner. Cell Cycle Analysis[2] Cell Line: BMMSC Concentration: 5 mM Incubation Time: 24 h Result: Induced the BMMSC cell cycle for cells to enter S phase from G0/G1 and arrested them from entering G2/M phase; the increased proportion of S phase in cell cycle was considered to be a sign of BMMSC proliferation. Western Blot Analysis[2] Cell Line: BMMSC Concentration: 0, 0.004, 0.02, 0.1, 0.5 and 2.5 mM Incubation Time: 0, 12, 24, 36, 48 h Result: Increased significantly the levels of p-ERK1/2 and p-Akt in a dose- and time-dependent manner.
References	[1]. Nomizu M, et al. The all-D-configuration segment containing the IKVAV sequence of laminin A chain has similar activities to the all-L-peptide in vitro and in vivo. J Biol Chem. 1992 Jul 15;267(20):14118-21. [2]. Li B, et al. IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation. Cell Prolif. 2014 Apr;47(2):133-45.

Density	1.1±0.1 g/cm3
Boiling Point	856.6±65.0 °C at 760 mmHg
Molecular Formula	C₂₅H₄₈N₆O₆
Molecular Weight	528.685
Flash Point	471.9±34.3 °C
Exact Mass	528.363525
LogP	1.27
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.511

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