106577-39-3

106577-39-3 structure

Name: Hederacolchiside A1
Chemical Name: Hederacolchiside A1
CAS Number: 106577-39-3
Molecular Formula: C₄₇H₇₆O₁₆
Molecular Weight: 897.097
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-12-29 17:24:34
Modify Date: 2024-01-02 20:05:29
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2].

Name	Hederacolchiside A1
Synonyms	(3β,5ξ,18α)-3-{[6-Deoxy-α-L-mannopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->4)]-α-L-arabinopyranosyl]oxy}olean-12-en-28-oic acid Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1->2)-O-[β-D-glucopyranosyl-(1->4)]-α-L-arabinopyranosyl]oxy]-, (3β,5ξ,18α)-

Description	Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	PI3K Akt mTOR
In Vitro	Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher[1]. Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) [1].
In Vivo	hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model[1]. Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells[1].
References	[1]. Yan-Er Wang, et al. Hederacolchiside A1 suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. Chinese Herbal Medicines.Volume 10, Issue 2, April 2018, Pages 215-222 [2]. Kang N, et al. Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis. Molecules. 2018 Jun 13;23(6).

Density	1.36±0.1 g/cm3 (20 ºC 760 Torr)
Boiling Point	967.2±65.0 °C at 760 mmHg
Melting Point	253-255℃ (methanol , water )
Molecular Formula	C₄₇H₇₆O₁₆
Molecular Weight	897.097
Flash Point	276.2±27.8 °C
Exact Mass	896.513306
LogP	7.36
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.610
Storage condition	2-8℃
Water Solubility	Insuluble (3.9E-4 g/L) (25 ºC)

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