DC Chemicals Limited
China
Product Name: JD5037
Price: $700.0/100mg $1350.0/250mg $2700.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1392116-14-1

1392116-14-1 structure

1392116-14-1 structure

Name: JD-5037
Chemical Name: JD5037
CAS Number: 1392116-14-1
Molecular Formula: C₂₇H₂₇Cl₂N₅O₃S
Molecular Weight: 572.506
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2018-05-04 09:12:48
Modify Date: 2024-01-06 15:49:40
JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.

Name	JD5037
Synonyms	(E)-N-([(4S)-3-(4-Chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl]{[(4-chlorophenyl)sulfonyl]amino}methylene)-L-valinamide JD5037 Butanamide, 2-[[(E)-[(4S)-3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl][[(4-chlorophenyl)sulfonyl]imino]methyl]amino]-3-methyl-, (2S)- JD-5037

Description	JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor Research Areas >> Metabolic Disease
Target	IC50: 1.5 nM (CB1R)[1]
In Vivo	JD5037 (3 mg/kg/d, i.p.) induces equal reductions in body weight, attenuates the HFD-induced hyperglycemia, and reduces the HFD-induced hepatic injury and steatosis in obese Magel2-null mice[2]. JD5037 (3 mg/kg/day, p.o.) significantly reduces the size of tumors and abrogates the tumor in DEN-treated mice. JD5037 attenuates the AEA levels in HCC samples from mice[3].
Animal Admin	Mice: JD-5037 is formulated in vehicle (V; 1% Tween80, 4% DMSO, 95% Saline). Obese mice are treated chronically (28 d) with vehicle (V; 1% Tween80, 4% DMSO, 95% Saline), JD5037, or SLV319 at a dose of 3 mg/kg, i.p. Body weight and food intake are monitored daily. Mice are euthanized by cervical dislocation under anesthesia; the brain, hypothalamus, liver, and combined fat pads are removed, weighed, and snap-frozen, and trunk blood is collected for determining the endocrine and biochemical parameters[2].
References	[1]. Chorvat RJ. Peripherally restricted CB1 receptor blockers. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4751-60. [2]. Knani I, et al. Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome. Mol Metab. 2016 Oct 22;5(12):1187-1199. [3]. Mukhopadhyay B, et al. Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms. Hepatology. 2015 May;61(5):1615-26.

Density	1.4±0.1 g/cm3
Boiling Point	731.3±70.0 °C at 760 mmHg
Molecular Formula	C₂₇H₂₇Cl₂N₅O₃S
Molecular Weight	572.506
Flash Point	396.1±35.7 °C
Exact Mass	571.121155
LogP	4.58
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.662
Storage condition	2-8℃