1356497-91-0

1356497-91-0 structure

Name: ST247
Chemical Name: 3-[[[4-(Hexylamino)-2-methoxyphenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl este
CAS Number: 1356497-91-0
Molecular Formula: C₁₉H₂₆N₂O₅S₂
Molecular Weight: 426.550
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2018-02-04 05:34:18
Modify Date: 2025-08-27 11:56:49
ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ[1].

Name	3-[[[4-(Hexylamino)-2-methoxyphenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl este
Synonyms	3-[[[4-(Hexylamino)-2-methoxyphenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester 2-Thiophenecarboxylic acid, 3-[[[4-(hexylamino)-2-methoxyphenyl]amino]sulfonyl]-, methyl ester Methyl 3-{[4-(hexylamino)-2-methoxyphenyl]sulfamoyl}-2-thiophenecarboxylate ST247

Description	ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	PPARβ/δ
In Vitro	ST247 induces a clearly enhanced interaction of the PPARβ/δ LBD with the SMRT-ID2 peptide, with an EC50 of 10 nM[1]. ST247 down-regulates basal level expression of the peroxisome proliferator responsive element-driven PPARβ/δ target gene ANGPTL4, with an IC50 of 19.1 nM[1].
References	[1]. Naruhn S, et al. High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic properties. Mol Pharmacol. 2011 Nov;80(5):828-38.

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H318
Precautionary Statements	P280-P305 + P351 + P338
RIDADR	NONH for all modes of transport