929007-72-7
929007-72-7 structure
- Name: DB07268
- Chemical Name: 2-({2-[(3-Hydroxyphenyl)amino]-4-pyrimidinyl}amino)benzamide
- CAS Number: 929007-72-7
- Molecular Formula: C17H15N5O2
- Molecular Weight: 321.333
- Catalog: Signaling Pathways MAPK/ERK Pathway JNK
- Create Date: 2019-01-10 08:19:15
- Modify Date: 2024-01-03 09:20:31
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DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.
| Name | 2-({2-[(3-Hydroxyphenyl)amino]-4-pyrimidinyl}amino)benzamide |
|---|---|
| Synonyms |
Benzamide, 2-[[2-[(3-hydroxyphenyl)amino]-4-pyrimidinyl]amino]-
2-({2-[(3-Hydroxyphenyl)amino]-4-pyrimidinyl}amino)benzamide MFCD26960941 DB07268 |
| Description | DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM. |
|---|---|
| Related Catalog | |
| Target |
JNK1:9 nM (IC50) CHK1:0.82 μM (IC50) PAK4:5.5 μM (IC50) AKT1:15 μM (IC50) ERK2:25 μM (IC50) |
| In Vitro | DB07268 (Compound 2b) also inhibits CHK1, PAK4, AKT1, and ERK2 with IC50s of 0.82 μM, 5.5 μM, 15 μM, and 25 μM, respectively[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 641.6±65.0 °C at 760 mmHg |
| Molecular Formula | C17H15N5O2 |
| Molecular Weight | 321.333 |
| Flash Point | 341.8±34.3 °C |
| Exact Mass | 321.122589 |
| LogP | 1.96 |
| Appearance | light yellow solid |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.753 |
| Storage condition | -20°C |