Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Pancreatic Polypeptide (human) trifluoroacetate salt
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

GL Biochem (Shanghai) Ltd.
China
Product Name: Pancreatic Polypeptide (human)
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Pancreatic Polypeptide (human) trifluoroacetate salt
Price: ￥Inquiry/1mg ￥2118.0/1mg ￥Inquiry/1mg
Purity: 95.0%
Stocking Period: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

75976-10-2

75976-10-2 structure

75976-10-2 structure

Name: Pancreatic Polypeptide (human) trifluoroacetate salt
Chemical Name: Pancreatic Polypeptide(Human)
CAS Number: 75976-10-2
Molecular Formula: C₁₈₅H₂₈₇N₅₃O₅₄S₂
Molecular Weight: 4181.71
Catalog: Biochemical Peptide
Create Date: 2018-04-21 08:00:00
Modify Date: 2025-08-22 20:19:34
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

Name	Pancreatic Polypeptide(Human)
Synonyms	MFCD00081812 Pancreatic Polypeptide (human) Pancreatic Polypeptide, human

Description	Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor Research Areas >> Metabolic Disease Peptides
Target	Neuropeptide Y (NPY) Y4/Y5 receptor[1]
In Vitro	Human pancreatic polypeptide (hPP) is one such peptide, being released postprandially from F cells of the pancreatic islets depending on caloric load, food consumption and circadian rhythm. It is a C-terminally amidated 36 amino acid peptide with a characteristic hairpin-like pancreatic polypeptide (PP)-fold and acts at the Y4 receptor to induce satiety and delay gastric emptying and motility[1]. Addition of the human pancreatic polypeptide (hPP) (10 nM-1 μM) results in a significant, dose-dependent reduction in both basal and stimulated release. Human pancreatic polypeptide (hPP) can also inhibit basal and stimulated NPY release with a pharmacological profile suggesting a role for Y4 presynaptic receptors[2].
References	[1]. Thieme V, et al. High molecular weight PEGylation of human pancreatic polypeptide at position 22 improvesstability and reduces food intake in mice. Br J Pharmacol. 2016 Nov;173(22):3208-3221. [2]. King PJ, et al. Regulation of neuropeptide Y release by neuropeptide Y receptor ligands and calcium channel antagonists in hypothalamic slices. J Neurochem. 1999 Aug;73(2):641-6.

Molecular Formula	C₁₈₅H₂₈₇N₅₃O₅₄S₂
Molecular Weight	4181.71
Storage condition	-15°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.