Pancreatic Polypeptide (human) trifluoroacetate salt

Modify Date: 2025-08-22 20:19:34

Pancreatic Polypeptide (human) trifluoroacetate salt structure	Common Name	Pancreatic Polypeptide (human) trifluoroacetate salt
	CAS Number	75976-10-2	Molecular Weight	4181.71
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈₅H₂₈₇N₅₃O₅₄S₂	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Pancreatic Polypeptide (human) trifluoroacetate salt

Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

Name	Pancreatic Polypeptide(Human)
Synonym	More Synonyms

Description	Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor Research Areas >> Metabolic Disease Peptides
Target	Neuropeptide Y (NPY) Y4/Y5 receptor[1]
In Vitro	Human pancreatic polypeptide (hPP) is one such peptide, being released postprandially from F cells of the pancreatic islets depending on caloric load, food consumption and circadian rhythm. It is a C-terminally amidated 36 amino acid peptide with a characteristic hairpin-like pancreatic polypeptide (PP)-fold and acts at the Y4 receptor to induce satiety and delay gastric emptying and motility[1]. Addition of the human pancreatic polypeptide (hPP) (10 nM-1 μM) results in a significant, dose-dependent reduction in both basal and stimulated release. Human pancreatic polypeptide (hPP) can also inhibit basal and stimulated NPY release with a pharmacological profile suggesting a role for Y4 presynaptic receptors[2].
References	[1]. Thieme V, et al. High molecular weight PEGylation of human pancreatic polypeptide at position 22 improvesstability and reduces food intake in mice. Br J Pharmacol. 2016 Nov;173(22):3208-3221. [2]. King PJ, et al. Regulation of neuropeptide Y release by neuropeptide Y receptor ligands and calcium channel antagonists in hypothalamic slices. J Neurochem. 1999 Aug;73(2):641-6.

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MFCD00081812

Pancreatic Polypeptide (human)

Pancreatic Polypeptide, human

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