DC Chemicals Limited
China
Product Name: PD-168077 maleate
Price: $550.0/100mg $950.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PD 168077 MALEATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

630117-19-0

630117-19-0 structure

630117-19-0 structure

Name: PD 168077 maleate
Chemical Name: N-{[4-(2-Cyanophenyl)-1-piperazinyl]methyl}-3-methylbenzamide (2Z)-2-butenedioate (1:1)
CAS Number: 630117-19-0
Molecular Formula: C₂₄H₂₆N₄O₅
Molecular Weight: 450.487
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-01-23 09:48:29
Modify Date: 2024-01-14 15:16:13
PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.

Name	N-{[4-(2-Cyanophenyl)-1-piperazinyl]methyl}-3-methylbenzamide (2Z)-2-butenedioate (1:1)
Synonyms	N-{[4-(2-Cyanophenyl)-1-piperazinyl]methyl}-3-methylbenzamide (2Z)-2-butenedioate (1:1) N-{[4-(2-Cyanophenyl)piperazin-1-yl]methyl}-3-methylbenzamide (2Z)-but-2-enedioate (1:1) Benzamide, N-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-3-methyl-, (2Z)-2-butenedioate (1:1)

Description	PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Ki: 9 nM (Dopamine D4 receptor)[1].
In Vitro	PD-168077 is one of the first agents to be identified as putative selective D4 agonists. It shows >100-fold selectivity over other members of the D2-like receptor family and over their D1-like counterparts; PD-168077 shows a 20-fold selectivity over α1, and α2, a 45-fold selectivity over 5-HT1A, and a 460-fold selectivity over 5-HT2A receptors; PD-168077 evidences intrinsic activity at the D4 receptor in terms of quinpirole-like inhibition of forskolin-stimulated cAMP accumulation or stimulation of [3H]thymidine uptake in CHO cells expressing the human D4 receptor[1]. In the PD-168077-treated cell, p-CaMKII exhibits a significantly increased clustering at synaptic sites, as indicated by the enhanced colocalization with PSD-95[2].
In Vivo	PD-168077 (0.2-25.0 mg/kg) dose-dependently induces locomotion, which takes an unusual and characteristic ”shuffling” form with uncoordinated movements together with yawning, and episodes of myoclonic jerking; grooming, and rearing are reduced[1].
References	[1]. Clifford JJ, et al. Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists. Neuropsychopharmacology. 2000 May;22(5):538-44. [2]. Gu Z, et al. Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol Pharmacol. 2006 Mar;69(3):813-22.

Molecular Formula	C₂₄H₂₆N₄O₅
Molecular Weight	450.487
Exact Mass	450.190308
Storage condition	2-8℃