162303-59-5

162303-59-5 structure

Name: EDTA, AM
Chemical Name: EDTA, AM [EDTA, tetra(acetoxyMethyl ester)]
CAS Number: 162303-59-5
Molecular Formula: C₂₂H₃₂N₂O₁₆
Molecular Weight: 580.49
Catalog: Research Areas Others
Create Date: 2018-02-17 22:33:01
Modify Date: 2024-01-17 18:23:55
EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation[1][2].

Name	EDTA, AM [EDTA, tetra(acetoxyMethyl ester)]
Synonyms	Acetoxymethyl 8,11-bis[2-(acetoxymethoxy)-2-oxoethyl]-2,6-dioxo-3,5-dioxa-8,11-diazatridecan-13-oate

Description	EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation[1][2].
Related Catalog	Research Areas >> Others
References	[1]. Watkins CS, et.al. Effects on K+ currents in rat cerebellar granule neurones of a membrane-permeable analogue of the calcium chelator BAPTA. Br J Pharmacol. 1996 Aug;118(7):1772-8. [2]. Maeshima K, et.al. A Transient Rise in Free Mg2+Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation. Curr Biol. 2018 Feb 5;28(3):444-451.e6.