1822358-25-7
1822358-25-7 structure
- Name: POL1-IN-1
- Chemical Name: 2-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzo[4,5]imidazo[1,2-a][1,8]naphthyridine-6-carbonitrile
- CAS Number: 1822358-25-7
- Molecular Formula: C21H20N6
- Molecular Weight: 356.42400
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2018-02-27 19:42:57
- Modify Date: 2025-08-27 13:02:01
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POL1-IN-1 is a RNA polymerase 1 (POL1, also known as Pol I) inhibitor with an IC50 of less than 0.5 uM. POL1-IN-1 inhibits ribosome biogenesis by inhibiting POL1 transcription[1].
| Name | 2-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzo[4,5]imidazo[1,2-a][1,8]naphthyridine-6-carbonitrile |
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| Description | POL1-IN-1 is a RNA polymerase 1 (POL1, also known as Pol I) inhibitor with an IC50 of less than 0.5 uM. POL1-IN-1 inhibits ribosome biogenesis by inhibiting POL1 transcription[1]. |
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| Related Catalog | |
| References |
[1]. Mustapha Haddach. Compositions, uses and methods for making them. US9758518B2. |
| Molecular Formula | C21H20N6 |
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| Molecular Weight | 356.42400 |
| Exact Mass | 356.17500 |
| PSA | 69.25000 |
| LogP | 3.48778 |
| Storage condition | -20°C |
| Hazard Codes | Xn |
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