218136-59-5
218136-59-5 structure
- Name: SC-26196
- Chemical Name: 2,2-Diphenyl-5-{4-[(E)-(3-pyridinylmethylene)amino]-1-piperazinyl}pentanenitrile
- CAS Number: 218136-59-5
- Molecular Formula: C27H29N5
- Molecular Weight: 423.553
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-03-23 00:11:26
- Modify Date: 2025-08-25 17:09:25
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SC-26196 is a potent, orally active Delta6 desaturase (D6D) inhibitor (IC50=0.2 µM in a rat liver microsomal assay). Antiinflammatory properties[1].
| Name | 2,2-Diphenyl-5-{4-[(E)-(3-pyridinylmethylene)amino]-1-piperazinyl}pentanenitrile |
|---|---|
| Synonyms |
1-Piperazinepentanenitrile, α,α-diphenyl-4-[[(1E)-3-pyridinylmethylene]amino]-
2,2-Diphenyl-5-{4-[(E)-(3-pyridinylmethylene)amino]-1-piperazinyl}pentanenitrile SC-26196 |
| Description | SC-26196 is a potent, orally active Delta6 desaturase (D6D) inhibitor (IC50=0.2 µM in a rat liver microsomal assay). Antiinflammatory properties[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.2 µM (Delta6 desaturase in a rat liver microsomal assay)[1] |
| In Vitro | SC-26196 (200 nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells[2]. Cell Proliferation Assay[2] Cell Line: PBMCs and Jurkat cells Concentration: 200 nM Incubation Time: 96 hours for PBMCs; 144 hours for Jurkat cells Result: Treatment of PBMCs significantly decreased the proportion of cells that underwent division, the division index and proliferation index. Did not alter cell proliferation significantly in Jurkat cells. |
| In Vivo | SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme[3]. Animal Model: Male mice (12- or 15-week-old)[3] Dosage: 0, 10, 30, and 100 mg/kg per day Administration: Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day. Result: Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 650.2±55.0 °C at 760 mmHg |
| Molecular Formula | C27H29N5 |
| Molecular Weight | 423.553 |
| Flash Point | 347.0±31.5 °C |
| Exact Mass | 423.242310 |
| LogP | 3.20 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.607 |