262451-89-8

262451-89-8 structure

Name: SC 22716
Chemical Name: 1-[2-(4-phenylphenoxy)ethyl]pyrrolidine
CAS Number: 262451-89-8
Molecular Formula: C₁₈H₂₁NO
Molecular Weight: 267.36500
Catalog: Signaling Pathways Metabolic Enzyme/Protease Aminopeptidase
Create Date: 2018-06-14 15:42:48
Modify Date: 2024-01-15 10:01:53
SC-22716 is a potent, competitive, reversible inhibitor of human LTA4 hydrolase, with an IC50 of 0.20 µM. SC-22716 has potential for the research of inflammatory bowel disease (IBD) and psoriasis[1].

Name	1-[2-(4-phenylphenoxy)ethyl]pyrrolidine
Synonyms	1-[2-(biphenyloxy)ethyl]pyrrolidine 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine

Description	SC-22716 is a potent, competitive, reversible inhibitor of human LTA4 hydrolase, with an IC50 of 0.20 µM. SC-22716 has potential for the research of inflammatory bowel disease (IBD) and psoriasis[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aminopeptidase Research Areas >> Inflammation/Immunology
References	[1]. Penning TD, et, al. Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase. J Med Chem. 2000 Feb 24;43(4):721-35.

Density	1.065g/cm3
Boiling Point	418.5ºC at 760 mmHg
Molecular Formula	C₁₈H₂₁NO
Molecular Weight	267.36500
Flash Point	122.8ºC
Exact Mass	267.16200
PSA	12.47000
LogP	3.76610
Vapour Pressure	3.27E-07mmHg at 25°C
Index of Refraction	1.568

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

92-69-3

7250-67-1

262451-89-8

Literature: Penning, Thomas D.; Chandrakumar, Nizal S.; Chen, Barbara B.; Chen, Helen Y.; Desai, Bipin N.; Djuric, Stevan W.; Docter, Stephen H.; Gasiecki, Alan F.; Haack, Richard A.; Miyashiro, Julie M.; Russell, Mark A.; Yu, Stella S.; Corley, David G.; Durley, Richard C.; Kilpatrick, Brian F.; Parnas, Barry L.; Askonas, Leslie J.; Gierse, James K.; Harding, Elizabeth I.; Highkin, Maureen K.; Kachur, James F.; Kim, Suzanne H.; Krivi, Gwen G.; Villani-Price, Doreen; Pyla, E. Yvonne; Smith, Walter G.; Ghoreishi-Haack, Nayereh S. Journal of Medicinal Chemistry, 2000 , vol. 43, # 4 p. 721 - 735

5050-41-9

92-69-3

262451-89-8

Literature: Adir et Compagnie Patent: US6339092 B1, 2002 ; Location in patent: Page column 5 ;

Precursor 3
92-69-3 7250-67-1 5050-41-9
DownStream 0

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