1003311-62-3
1003311-62-3 structure
- Name: c-Kit-IN-5-1
- Chemical Name: 3-(2-Amino-6-quinazolinyl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]-2(1H)-pyridinone
- CAS Number: 1003311-62-3
- Molecular Formula: C23H17N5O2
- Molecular Weight: 395.413
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Kit
- Create Date: 2018-01-11 15:31:35
- Modify Date: 2025-08-25 15:40:35
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c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties[1].
| Name | 3-(2-Amino-6-quinazolinyl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]-2(1H)-pyridinone |
|---|---|
| Synonyms |
2(1H)-Pyridinone, 3-(2-amino-6-quinazolinyl)-4-methyl-1-[4-(2-oxazolyl)phenyl]-
3-(2-Amino-6-quinazolinyl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]-2(1H)-pyridinone AMG-25 |
| Description | c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties[1]. |
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| Related Catalog | |
| In Vitro | c-Kit-IN-5 (compound 25) shows more than 200-fold selectivity against KDR, p38, Lck, and Src (IC50=>5.0, 40, 7.8 , and >5.0 μM, respectively)[1]. |
| In Vivo | c-Kit-IN-5 (compound 25) (1 mg/kg; i.v.) exhibits CL (0.46 L/h/kg) and Vdss (1.59 L/kg) in rats[1]. c-Kit-IN-5 (10 mg/kg; p.o.) exhibits AUC0-t(9860 ng•h/mL) Cmax(1230 ng/mL), T1/2 (2.6 h), and F (39%) in rats[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 720.7±70.0 °C at 760 mmHg |
| Molecular Formula | C23H17N5O2 |
| Molecular Weight | 395.413 |
| Flash Point | 389.7±35.7 °C |
| Exact Mass | 395.138214 |
| LogP | 2.78 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.709 |
| Storage condition | -20°C |
| Hazard Codes | Xn |
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