521310-51-0

521310-51-0 structure

Name: MCP110
Chemical Name: N-[4-(Benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(2-pyridinyl)ethyl]pentanamide
CAS Number: 521310-51-0
Molecular Formula: C₃₃H₃₆N₂O₃
Molecular Weight: 508.651
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2018-04-24 09:17:15
Modify Date: 2024-01-30 00:37:11
MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf[1].

Name	N-[4-(Benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(2-pyridinyl)ethyl]pentanamide
Synonyms	Benzenepentanamide, N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-N-[2-(2-pyridinyl)ethyl]- N-[4-(benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(pyridin-2-yl)ethyl]pentanamide N-[4-(Benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(2-pyridinyl)ethyl]pentanamide N-(4-(benzyloxy)-3-methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanamide MCP110

Description	MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras Signaling Pathways >> MAPK/ERK Pathway >> Raf
Target	Ras RAF
In Vitro	MCP110 (10 and 20 uM) inhibits H-Ras (V12)-induced AP-1 activation in HEK293 cells. Ras stimulation of Raf-1 activity is significantly decreased by MCP110 (20 μM) [1]. MCP110 (1, 2, 5, 10, and 20 μM) shows a dose-dependent inhibition of elevated Raf-1 activity in fibrosarcoma HT1080 cells[1]. MCP110 (20 μM) decreases cyclin D level stimulated by the treatment with EGF (100 ng/mL), platelet-derived growth factor (20 ng/mL) , serum, or phorbol 12-myristate 13-acetate (100 nM) in A549 cells[1].
References	[1]. Juran Kato-Stankiewicz,et al. Inhibitors of Ras/Raf-1 Interaction Identified by Two-Hybrid Screening Revert Ras-dependent Transformation Phenotypes in Human Cancer Cells. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14398-403.