MCP110

Modify Date: 2024-01-30 00:37:11

MCP110 Structure
MCP110 structure
Common Name MCP110
CAS Number 521310-51-0 Molecular Weight 508.651
Density 1.1±0.1 g/cm3 Boiling Point 686.3±55.0 °C at 760 mmHg
Molecular Formula C33H36N2O3 Melting Point N/A
MSDS N/A Flash Point 368.8±31.5 °C

 Use of MCP110


MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf[1].

 Names

Name N-[4-(Benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(2-pyridinyl)ethyl]pentanamide
Synonym More Synonyms

 MCP110 Biological Activity

Description MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf[1].
Related Catalog
Target

Ras

RAF

In Vitro MCP110 (10 and 20 uM) inhibits H-Ras (V12)-induced AP-1 activation in HEK293 cells. Ras stimulation of Raf-1 activity is significantly decreased by MCP110 (20 μM) [1]. MCP110 (1, 2, 5, 10, and 20 μM) shows a dose-dependent inhibition of elevated Raf-1 activity in fibrosarcoma HT1080 cells[1]. MCP110 (20 μM) decreases cyclin D level stimulated by the treatment with EGF (100 ng/mL), platelet-derived growth factor (20 ng/mL) , serum, or phorbol 12-myristate 13-acetate (100 nM) in A549 cells[1].
References

[1]. Juran Kato-Stankiewicz,et al. Inhibitors of Ras/Raf-1 Interaction Identified by Two-Hybrid Screening Revert Ras-dependent Transformation Phenotypes in Human Cancer Cells. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14398-403.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 686.3±55.0 °C at 760 mmHg
Molecular Formula C33H36N2O3
Molecular Weight 508.651
Flash Point 368.8±31.5 °C
Exact Mass 508.272583
LogP 6.24
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.594

 Synonyms

Benzenepentanamide, N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-N-[2-(2-pyridinyl)ethyl]-
N-[4-(benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(pyridin-2-yl)ethyl]pentanamide
N-[4-(Benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(2-pyridinyl)ethyl]pentanamide
N-(4-(benzyloxy)-3-methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanamide
MCP110
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