138529-04-1

138529-04-1 structure

Name: Diphlorethohydroxycarmalol
Chemical Name: diphlorethohydroxycarmalol
CAS Number: 138529-04-1
Molecular Formula: C₂₄H₁₆O₁₃
Molecular Weight: 512.38
Catalog: Research Areas Metabolic Disease
Create Date: 2018-06-29 19:33:05
Modify Date: 2024-01-10 10:22:36
Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and α-amylase inhibitor with IC50s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities[1].

Name	diphlorethohydroxycarmalol
Synonyms	7-(3,5-Dihydroxy-phenoxy)-3-(2,4,6-trihydroxy-phenoxy)-dibenzo[1,4]dioxine-1,2,6,8-tetraol

Description	Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active α-glucosidase and α-amylase inhibitor with IC50s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	IC50: 0.16 mM (α-glucosidase) and 0.53 mM (α-amylase) [1]
In Vivo	The increase of postprandial blood glucose levels are significantly suppressed in the Diphlorethohydroxycarmalol-administered group than those in the streptozotocin-induced diabetic or normal mice. Moreover, the area under curve (AUC) is significantly reduced via Diphlorethohydroxycarmalol (100 mg/kg; p.o.) administration (2022 versus 2210 mmol x min/lL) in the diabetic mice as well as it delays absorption of dietary carbohydrates[1].
References	[1]. Soo-Jin Heo, et al. Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice. Eur J Pharmacol. 2009 Aug 1;615(1-3):252-6.