38874-46-3

38874-46-3 structure

Name: 8-Azanebularine
Chemical Name: 8-azanebularine ribonucleoside
CAS Number: 38874-46-3
Molecular Formula: C₉H₁₁N₅O₄
Molecular Weight: 253.21500
Catalog: Research Areas Others
Create Date: 2018-06-18 18:14:45
Modify Date: 2025-09-18 08:24:07
8-Azanebularine, a compound with hydrogen in place of the C6 amino group, inhibits the ADAR2 reaction at high concentrations (IC50=15 mM). 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (KD=2 nM). 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction[1].

Name	8-azanebularine ribonucleoside
Synonyms	8-azanebularine 1-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl-β-D-1-deoxy-ribofuranose (2R,3S,4R,5R)-2-Hydroxymethyl-5-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl-tetrahydro-furan-3,4-diol 8-Azanebutarin

Description	8-Azanebularine, a compound with hydrogen in place of the C6 amino group, inhibits the ADAR2 reaction at high concentrations (IC50=15 mM). 8-Azanebularine is incorporated into an RNA structure recognized by human ADAR2 results in high-affinity binding (KD=2 nM). 8-Azanebularine can be used for the research of ADAR-catalyzed RNA-editing reaction[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	ADAR2 reaction:15 mM (IC50) ADAR2:2 nM (Kd)
References	[1]. Haudenschild BL, et al. A transition state analogue for an RNA-editing reaction. J Am Chem Soc. 2004;126(36):11213-11219.