207671-44-1

207671-44-1 structure

Name: Quinine hemisulfate hydrate
Chemical Name: Hydrogen sulfate-(8α,9R)-6'-methoxycinchonan-9-ol hydrate (2:1: 2:2)
CAS Number: 207671-44-1
Molecular Formula: C₂₀H₂₄N₂O_2.1/₂H₂O₄S_.H₂O
Molecular Weight: 782.94300
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-07-08 20:14:40
Modify Date: 2024-01-24 17:03:27
Quinine hemisulfate hydrate is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].

Name	Hydrogen sulfate-(8α,9R)-6'-methoxycinchonan-9-ol hydrate (2:1: 2:2)
Synonyms	Quinine hemisulfate Quinine sulfate

Description	Quinine hemisulfate hydrate is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: Parasite[1], 169 μM (mSlo3)[2]
References	[1]. Jane Achan , et al. Quinine, an Old Anti-Malarial Drug in a Modern World: Role in the Treatment of Malaria. Malar J. 2011 May 24;10:144. [2]. Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172(17):4355-63.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
RIDADR	NONH for all modes of transport