145600-69-7
145600-69-7 structure
- Name: AD 0261
- Chemical Name: 2-[3-[4-(4,4'-difluorobenzhydryl)piperazino]propyl]amino-4-methylphenol
- CAS Number: 145600-69-7
- Molecular Formula: C27H31F2N3O
- Molecular Weight: 451.55100
- Catalog: Research Areas Others
- Create Date: 2018-04-13 12:22:04
- Modify Date: 2024-01-08 17:48:09
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AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions.
| Name | 2-[3-[4-(4,4'-difluorobenzhydryl)piperazino]propyl]amino-4-methylphenol |
|---|---|
| Synonyms |
2-(3-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-propylamino)-4-methyl-phenol
AD 0261 |
| Description | AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions. |
|---|---|
| Related Catalog | |
| In Vitro | AD 0261 displays strong inhibitory action on the generation of lipid peroxides (IC50=0.022 μM) and superoxide anions (IC50= 0.9-4.0 μM). AD 0261 inhibits cytokine release and/or production from PHA-P-stimulated lymphocytes in a dose-dependent manner. AD 0261 inhibits all parameters which are indicative of lymphocyte activation with 50% inhibition being achieved in a range of 1-10 μM. AD 0261 suppresses ornithine decarboxylase activity, the IC50 value being around 1.0 μM[1]. |
| Cell Assay | For measurement of [3H]TdR incorporation, cells are incubated for 16 h and additional (6 h) incubation is carried out in the presence of [3H]TdR (0.5 μCi/well). [3H]TdR incorporation is evaluated in a liquid scintillation counter. IL-2 release from lymphocytes is estimated after 20 h incubation by enzyme immunoassay using the commercially available kits. IL-2 receptor expression is quantitated by flow-cytometry using an FITC-labelled monoclonal antibody which recognizes achain of IL-2 receptor complex. Cell viability is determined by either trypan blue exclusion test or propidium iodide staining. |
| References |
| Molecular Formula | C27H31F2N3O |
|---|---|
| Molecular Weight | 451.55100 |
| Exact Mass | 451.24400 |
| PSA | 38.74000 |
| LogP | 5.13680 |
| Storage condition | 2-8℃ |