188713-69-1

188713-69-1 structure

Name: Temporin A
Chemical Name: flpligrvlsgil-nh2
CAS Number: 188713-69-1
Molecular Formula: C₆₈H₁₁₇N₁₇O₁₄
Molecular Weight: 1396.76000
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-06-13 04:06:48
Modify Date: 2025-08-22 23:31:54
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans)[1][1][3].

Name	flpligrvlsgil-nh2
Synonyms	FLPLIGRVLSGIL temporin A

Description	Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans)[1][1][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Temporin A (TA) is a small, basic, highly hydrophobic, antimicrobial peptide amide (FLPLIGRVLSGIL-NH2) found in the skin of the European red frog, Rana temporaria. It has variable antibiotic activities against a broad spectrum of microorganisms, including clinically important Methicillin-sensitive and -resistant Staphylococcus aureus as well as Vancomycin-resistant Enterococcus faecium strains[2].
References	[1]. Mäntylä T, Sirola H, Kansanen E, et al. Effect of temporin A modifications on its cytotoxicity and antimicrobial activity. APMIS. 2005;113(7-8):497-505. [2]. Wade D, et al. Antibacterial activities of temporin A analogs. FEBS Lett. 2000;479(1-2):6-9. [3]. Kamysz W, et al. Temporin A and its retro-analogues: synthesis, conformational analysis and antimicrobial activities. J Pept Sci. 2006;12(8):533-537.