32665-11-5

32665-11-5 structure

Name: Mercaptoethylguanidine (MEG) (dihydrobromide)
Chemical Name: S-(2-Amino-ethyl)-isothiuroniumbromid-hydrobromid
CAS Number: 32665-11-5
Molecular Formula: C₃H₁₀BrN₃S
Molecular Weight: 200.10100
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2018-03-24 13:29:40
Modify Date: 2024-01-08 17:14:55
Mercaptoethylguanidine (MEG) dihydrobromide is selective inhibitor of the inducible nitric oxide synthase and peroxynitrite scavenger. Mercaptoethylguanidine (MEG) dihydrobromide has the potential for inflammatory bowel diseases research.

Name	S-(2-Amino-ethyl)-isothiuroniumbromid-hydrobromid
Synonyms	mercaptoethylguanidine (meg) dihydrobromide

Description	Mercaptoethylguanidine (MEG) dihydrobromide is selective inhibitor of the inducible nitric oxide synthase and peroxynitrite scavenger. Mercaptoethylguanidine (MEG) dihydrobromide has the potential for inflammatory bowel diseases research.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
In Vivo	Mercaptoethylguanidine (MEG; 10 mg/kg i.v. b. i.d.) dihydrobromide significantly reduces the appearance of diarrhea and the loss of body weight in male rats with colitis[1]. Mercaptoethylguanidine (10 mg/kg/day; ip; for 5 days) dihydrobromide ameliorates oxidative stress parameters and antioxidant enzyme activities in forty-five Sprague-Dawley rats weighing 200 to 250 g with esophagus uninjured[2].
References	[1]. B Zingarelli, et al. Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J Pharmacol Exp Ther. 1998 Dec;287(3):1048-55. [2]. Ahmet Guven, et al. Mercaptoethylguanidine attenuates caustic esophageal injury in rats: a role for scavenging of peroxynitrite. J Pediatr Surg. 2011 Sep;46(9):1746-52.