639089-06-8

639089-06-8 structure

Name: VUF 5681 dihydrobromide
Chemical Name: 4-[3-(1H-imidazol-5-yl)propyl]piperidine,dihydrobromide
CAS Number: 639089-06-8
Molecular Formula: C₁₁H₂₁Br₂N₃
Molecular Weight: 355.11
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2017-10-28 01:19:33
Modify Date: 2024-02-04 15:05:54
VUF 5681 dihydrobromide is a neutral antagonist of histamine H3 receptor. VUF 5681 dihydrobromide also has partial agonist function of H3 receptor. VUF 5681 dihydrobromide blocks the effects of Thioperamide (HY-12206). VUF 5681 dihydrobromide is used in central nervous system disease research[1][2].

Name	4-[3-(1H-imidazol-5-yl)propyl]piperidine,dihydrobromide
Synonyms	Pentoxyresorufin VUF 5681 dihydrobromide

Description	VUF 5681 dihydrobromide is a neutral antagonist of histamine H3 receptor. VUF 5681 dihydrobromide also has partial agonist function of H3 receptor. VUF 5681 dihydrobromide blocks the effects of Thioperamide (HY-12206). VUF 5681 dihydrobromide is used in central nervous system disease research[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H3 receptor
References	[1]. Moreno-Delgado D, et al. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology. 2006 Sep;51(3):517-23. [2]. Baker JG. Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. BMC Pharmacol. 2008 Jun 6;8:9.