133406-29-8
133406-29-8 structure
- Name: ST 034307
- Chemical Name: 6-chloro-2-(trichloromethyl)-4H-chromen-4-one
- CAS Number: 133406-29-8
- Molecular Formula: C10H4Cl4O2
- Molecular Weight: 297.95000
- Catalog: Signaling Pathways GPCR/G Protein Adenylate Cyclase
- Create Date: 2018-05-30 02:29:38
- Modify Date: 2024-01-04 21:46:06
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ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.
| Name | 6-chloro-2-(trichloromethyl)-4H-chromen-4-one |
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| Synonyms | ST034307 |
| Description | ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM. |
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| Related Catalog | |
| Target |
IC50: 2.3 μM (AC1)[1] |
| In Vitro | ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 significantly inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. In contrast, ST034307 has no significant effects in the wild-type HEK cells. ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1[1]. |
| In Vivo | ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model[1]. |
| Cell Assay | Cell viability assays are conducted with HEK-AC1 cells following plating and compound incubation protocols identical to the procedures described in “cAMP accumulation in cells.” Cell viability is measured as a percentage of vehicle using 2% Triton X-100 as a control. The CellTiter-Glo Luminescent Cell Viability Assay kit from Promega is used to assess cell viability according to the manufacturer’s instructions. Luminescence counts are measured using Synergy 4. |
| References |
| Molecular Formula | C10H4Cl4O2 |
|---|---|
| Molecular Weight | 297.95000 |
| Exact Mass | 295.89700 |
| PSA | 30.21000 |
| LogP | 4.27310 |
| Storage condition | 2-8℃ |