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924-42-5

924-42-5 structure
924-42-5 structure
Name N-(Hydroxymethyl)acrylamide
Synonyms N-(hydroxymethyl)prop-2-enamide
N-(Hydroxymethyl)acrylamide
N-hydroxymethylacrylamide
EINECS 213-103-2
2-Propenamide, N-(hydroxymethyl)-
N-Methylolacrylamide
MFCD00004597
Density 1.074
Boiling Point 318.1±34.0 °C at 760 mmHg
Melting Point 74-75°C
Molecular Formula C4H7NO2
Molecular Weight 101.104
Flash Point 146.2±25.7 °C
Exact Mass 101.047676
PSA 49.33000
LogP -1.48
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.459
Storage condition Refrigerator
Water Solubility <0.1 g/100 mL at 20.5 ºC

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AS3600000
CHEMICAL NAME :
Acrylamide, N-(hydroxymethyl)-
CAS REGISTRY NUMBER :
924-42-5
BEILSTEIN REFERENCE NO. :
0506646
LAST UPDATED :
199712
DATA ITEMS CITED :
27
MOLECULAR FORMULA :
C4-H7-N-O2
MOLECULAR WEIGHT :
101.12
WISWESSER LINE NOTATION :
Q1MV1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
474 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
563 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
16 gm/kg
TOXIC EFFECTS :
Behavioral - tremor
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8736 mg/kg/27W-C
TOXIC EFFECTS :
Behavioral - muscle weakness
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2400 mg/kg/16D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3250 mg/kg/13W-I
TOXIC EFFECTS :
Behavioral - ataxia Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4688 mg/kg/8W-I
TOXIC EFFECTS :
Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1625 mg/kg/13W-I
TOXIC EFFECTS :
Behavioral - ataxia Liver - changes in liver weight Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4800 mg/kg/16D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25750 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4608 mg/kg
SEX/DURATION :
male 16 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
730 gm/kg
SEX/DURATION :
male 6 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
730 gm/kg
SEX/DURATION :
male 6 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
TYPE OF TEST :
Sperm Morphology

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
250 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-352,1989 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,435,1994 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,435,1994 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,435,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81901 No. of Facilities: 154 (estimated) No. of Industries: 7 No. of Occupations: 17 No. of Employees: 2938 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81901 No. of Facilities: 117 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 20665 (estimated) No. of Female Employees: 13852 (estimated)
Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H301-H317-H340-H350-H361-H372
Precautionary Statements P201-P280-P301 + P310 + P330-P333 + P313
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S26
RIDADR 2810
WGK Germany 3
RTECS AS3600000
HS Code 2924199090
50-00-0 structure

50-00-0

107-06-2 structure

107-06-2

79-06-1 structure

79-06-1

~%

924-42-5 structure

924-42-5

Literature: Journal of the American Chemical Society, , vol. 75, p. 5027
50-00-0 structure

50-00-0

79-06-1 structure

79-06-1

~%

924-42-5 structure

924-42-5

Literature: Justus Liebigs Annalen der Chemie, , vol. 697, p. 171 - 180
50-00-0 structure

50-00-0

121-44-8 structure

121-44-8

79-06-1 structure

79-06-1

~%

924-42-5 structure

924-42-5

Literature: US2864861 , ;
HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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