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China
Product Name: Menadiol
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Purity: 98.0%
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481-85-6

481-85-6 structure

481-85-6 structure

Name: Menadiol
Chemical Name: menadiol
CAS Number: 481-85-6
Molecular Formula: C₁₁H₁₀O₂
Molecular Weight: 174.19600
Catalog: API Vitamins and minerals Vitamin C drugs
Create Date: 2018-03-24 08:00:00
Modify Date: 2024-01-02 14:27:30
Menadiol (Dihydrovitamin K3), a menaquinol analogue, is an electron donor for reversed oxidative phosphorylation in submitochondrial particles[1].

Name	menadiol
Synonyms	Methylnaphthohydroquinone 2-methylnaphthalene-1,4-diol Reduced vitamin K3 Menadiol EINECS 207-573-8 2-methyl-1,4-naphthalenediol Dihydrovitamin K3 2-Methyl-1,4-naphthalindiol Vitamin K3H2 Reduced menadione protrombrovit 2-Methyl-1,4-naphthohydroquinone 2-methyl-1,4-dihydroxynaphthalene

Description	Menadiol (Dihydrovitamin K3), a menaquinol analogue, is an electron donor for reversed oxidative phosphorylation in submitochondrial particles[1].
Related Catalog	Research Areas >> Others
References	[1]. Zhao Z, et al. Effects of site-directed mutations on heme reduction in Escherichia coli nitrate reductase A by menaquinol: a stopped-flow study. Biochemistry. 2003;42(48):14225-14233. [2]. Taggart WV, et al. Menadiol as an electron donor for reversed oxidative phosphorylation in submitochondrial particles. Biochim Biophys Acta. 1972;267(3):439-443.

Density	1.274g/cm3
Boiling Point	391.6ºC at 760mmHg
Melting Point	181℃
Molecular Formula	C₁₁H₁₀O₂
Molecular Weight	174.19600
Flash Point	199.5ºC
Exact Mass	174.06800
PSA	40.46000
LogP	2.55940
Vapour Pressure	1.08E-06mmHg at 25°C
Index of Refraction	1.697

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ5075000

CHEMICAL NAME :: 1,4-Naphthalenediol, 2-methyl-

CAS REGISTRY NUMBER :: 481-85-6

BEILSTEIN REFERENCE NO. :: 1638194

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H10-O2

MOLECULAR WEIGHT :: 174.21

WISWESSER LINE NOTATION :: L66J BQ C1 EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 75,111,1942

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 143,585,1949

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,210,1941

Hazard Codes	C

Precursor 9
58-27-5 1515-76-0 553-97-9 881-03-8
95-71-6 95-48-7 67597-84-6 53772-19-3
39055-47-5
DownStream 9
21564-92-1 58-27-5 139553-29-0 26271-55-6
2197-57-1 5519-38-0 78265-13-1 84-80-0
84-81-1