301687-87-6

301687-87-6 structure

Name: CCR-11
Chemical Name: (5E)-2-Thioxo-5-({5-[3-(trifluoromethyl)phenyl]-2-furyl}methylene)-1,3-thiazolidin-4-one
CAS Number: 301687-87-6
Molecular Formula: C₁₅H₈F₃NO₂S₂
Molecular Weight: 355.355
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-06-13 11:05:01
Modify Date: 2025-08-25 10:49:25
CCR-11 is an antibacterial agent. CCR-11 can inhibit the proliferation of B. subtilis cells with an IC50 value of 1.2 μM. CCR-11 inhibits HeLa cell proliferation with an IC50 value of 18.1 μM. CCR-11 inhibits bacterial cytokinesis by inhibiting FtsZ assembly. CCR-11 can be used for the research of FtsZ-targeted antibacterial agents[1].

Name	(5E)-2-Thioxo-5-({5-[3-(trifluoromethyl)phenyl]-2-furyl}methylene)-1,3-thiazolidin-4-one
Synonyms	4-Thiazolidinone, 2-thioxo-5-[[5-[3-(trifluoromethyl)phenyl]-2-furanyl]methylene]-, (5E)- (5E)-2-Thioxo-5-({5-[3-(trifluoromethyl)phenyl]-2-furyl}methylene)-1,3-thiazolidin-4-one

Description	CCR-11 is an antibacterial agent. CCR-11 can inhibit the proliferation of B. subtilis cells with an IC50 value of 1.2 μM. CCR-11 inhibits HeLa cell proliferation with an IC50 value of 18.1 μM. CCR-11 inhibits bacterial cytokinesis by inhibiting FtsZ assembly. CCR-11 can be used for the research of FtsZ-targeted antibacterial agents[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 1.2 μM (B. subtilis); 18.1 μM (HeLa cell) [1].
References	[1]. Singh P, et al. A rhodanine derivative CCR-11 inhibits bacterial proliferation by inhibiting the assembly and GTPase activity of FtsZ. Biochemistry. 2012 Jul 10;51(27):5434-42.