1092539-44-0

1092539-44-0 structure

Name: SAR131675
Chemical Name: (+/-)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
CAS Number: 1092539-44-0
Molecular Formula: C₁₈H₂₂N₄O₄
Molecular Weight: 358.392
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2016-05-07 08:03:06
Modify Date: 2024-01-11 10:30:13
(Rac)-SAR131675 is the racemate of SAR131675. SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM[1][2].

Name	(+/-)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
Synonyms	sar-131675 1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl]-N-methyl-4-oxo- 2-Amino-1-ethyl-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl]-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide SAR131675

Description	(Rac)-SAR131675 is the racemate of SAR131675. SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM[1][2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR Research Areas >> Neurological Disease
Target	VEGFR3
In Vitro	SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM[1][2].
References	[1]. Mitroshina EV, et al. Neuroprotective Effect of Kinase Inhibition in Ischemic Factor Modeling In Vitro. Int J Mol Sci. 2021;22(4):1885. [2]. Alam A, et al. SAR131675, a potent and selective VEGFR-3-TK inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. Mol Cancer Ther. 2012 Aug;11(8):1637-49.