62949-77-3

62949-77-3 structure

Name: Kuwanon A
Chemical Name: Kuwanon A
CAS Number: 62949-77-3
Molecular Formula: C₂₅H₂₄O₆
Molecular Weight: 420.45400
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2018-05-17 08:00:00
Modify Date: 2024-01-09 18:57:44
Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.

Name	Kuwanon A
Synonyms	kuwanon A 5,7,5'-trihydroxy-2',2'-dimethyl-3-(3-methyl-but-2-enyl)-2'H-[2,8']bichromenyl-4-one Kuwanon

Description	Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	IC50: 10.5 μM (nitric oxide)[1]
In Vitro	Kuwanon A shows significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes with TG inhibition values of 47.1%. Kuwanon A also shows significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells with an IC50 of 10.5 μM[1].
Cell Assay	RAW264.7 cells are treated with Kuwanon A (3, 10, 20, 30, 100 μM). Cell viability is measured using the MTT assay[1].
References	[1]. Yang ZG, et al. Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells. Molecules. 2011 Jul 19;16(7):6010-22.