1029044-16-3
1029044-16-3 structure
- Name: Pexidartinib
- Chemical Name: Pexidartinib
- CAS Number: 1029044-16-3
- Molecular Formula: C20H15ClF3N5
- Molecular Weight: 417.815
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Fms
- Create Date: 2018-08-13 20:35:29
- Modify Date: 2024-01-03 07:41:02
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Pexidartinib (PLX-3397) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13 nM, 27 nM, and 11 nM for CSF1R, c-Kit, and FLT3, respectively.
| Name | Pexidartinib |
|---|---|
| Synonyms |
PLX3397
5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)-3-pyridinyl]methyl}-2-pyridinamine 3-Pyridinemethanamine, N-[5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)- N-[5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine PLX-3397 pexidartinib |
| Description | Pexidartinib (PLX-3397) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13 nM, 27 nM, and 11 nM for CSF1R, c-Kit, and FLT3, respectively. |
|---|---|
| Related Catalog | |
| Target |
IC50: 28 nM (c-Fms), 16 nM (c-Kit) |
| In Vivo | Pexidartinib is a potent drug for treatment of cancer and used for Phase III TGCT clinical trial[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 580.0±50.0 °C at 760 mmHg |
| Molecular Formula | C20H15ClF3N5 |
| Molecular Weight | 417.815 |
| Flash Point | 304.6±30.1 °C |
| Exact Mass | 417.096802 |
| PSA | 66.49000 |
| LogP | 4.77 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.662 |
| Storage condition | -20℃ |
| Hazard Codes | N |
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