86270-92-0
86270-92-0 structure
- Name: NNK-d3, 4-(Methyl-d3-nitrosoamino)-1-(3-pyridinyl)-1-butanone
- Chemical Name: N-(4-oxo-4-pyridin-3-ylbutyl)-N-(trideuteriomethyl)nitrous amide
- CAS Number: 86270-92-0
- Molecular Formula: C10H10D3N3O2
- Molecular Weight: 210.24800
- Catalog: analytical chemistry Standard Food and beverage standards
- Create Date: 2017-10-08 09:00:20
- Modify Date: 2025-09-04 17:14:03
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NNK-d3 is the deuterium labeled NNK (HY-126477)[1][2].
| Name | N-(4-oxo-4-pyridin-3-ylbutyl)-N-(trideuteriomethyl)nitrous amide |
|---|---|
| Synonyms | NNK-d3 |
| Description | NNK-d3 is the deuterium labeled NNK (HY-126477)[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 NNK (100 pM；0-60 分钟) 刺激 PKCα 和 MAPKs ERK1/2 的激活，直接诱导 c-Myc 磷酸化[2]。 NNK (100 pM；96 小时) 增强 WT 细胞增殖，但不影响表达 AA 的 c-Myc 突变体[2]。 |
| References |
| Density | 1.17g/cm3 |
|---|---|
| Boiling Point | 423.9ºC at 760 mmHg |
| Molecular Formula | C10H10D3N3O2 |
| Molecular Weight | 210.24800 |
| Flash Point | 210.2ºC |
| Exact Mass | 210.12000 |
| PSA | 62.63000 |
| LogP | 1.65770 |
| Index of Refraction | 1.557 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H317 |
| Precautionary Statements | P280-P301 + P310 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 22-43 |
| Safety Phrases | 36/37 |
| RIDADR | UN 2811 6.1 / PGIII |