186901-48-4

186901-48-4 structure

Name: Cortistatin 14
Chemical Name: Cortistatin-14
CAS Number: 186901-48-4
Molecular Formula: C₈₁H₁₁₄N₂₀O₁₈S₂
Molecular Weight: 1721.01000
Catalog: Biochemical Peptide
Create Date: 2018-03-24 08:00:00
Modify Date: 2025-08-26 22:30:08
Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties[1][2][3][4].

Name	Cortistatin-14
Synonyms	cortistatin14 Cortistatin 14

Description	Cortistatin-14, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties[1][2][3][4].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
References	[1]. De Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5. [2]. Baranowska B, et al. Cortistatin and pituitary hormone secretion in rat. J Physiol Pharmacol. 2009 Mar;60(1):151-6. [3]. Braun H, et al. Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain. Brain Res. 1998 Aug 24;803(1-2):54-60. [4]. Markovics A, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50.

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