134865-70-6
134865-70-6 structure
- Name: 8-M-PDOT
- Chemical Name: N-[(2R)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]propanamide
- CAS Number: 134865-70-6
- Molecular Formula: C14H19NO2
- Molecular Weight: 233.30600
- Catalog: Signaling Pathways GPCR/G Protein Melatonin Receptor
- Create Date: 2018-09-03 12:12:31
- Modify Date: 2024-01-13 11:33:04
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8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2].
| Name | N-[(2R)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]propanamide |
|---|---|
| Synonyms |
8-methoxy-2-propionamidotetralin
Tocris-1035 8-M-PDOT |
| Description | 8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2]. |
|---|---|
| Related Catalog | |
| Target |
pKi: 8.23 (Melatonin MT2 receptor) and 8.95 (Melatonin MT1 receptor)[2] |
| In Vivo | 8-M-PDOT (10 µg/µL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect[2]. Animal Model: Male Wistar rats (280-320 g) with Rotenone[2] Dosage: 10 µg/µL Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes Result: Increased percentage of time spent in the open arms and in the number of open arms entries. |
| References |
| Density | 1.09g/cm3 |
|---|---|
| Boiling Point | 447.8ºC at 760 mmHg |
| Molecular Formula | C14H19NO2 |
| Molecular Weight | 233.30600 |
| Flash Point | 224.6ºC |
| Exact Mass | 233.14200 |
| PSA | 38.33000 |
| LogP | 2.46960 |
| Vapour Pressure | 3.27E-08mmHg at 25°C |
| Index of Refraction | 1.542 |
