120447-62-3
120447-62-3 structure
- Name: AH-5183 hydrochloride
- Chemical Name: (±)-Vesamicol hydrochloride
- CAS Number: 120447-62-3
- Molecular Formula: C17H26ClNO
- Molecular Weight: 295.84700
- Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
- Create Date: 2016-02-21 06:40:02
- Modify Date: 2024-01-04 14:07:11
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(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. (±)-Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively[1][2].
| Name | (±)-Vesamicol hydrochloride |
|---|---|
| Synonyms |
(+/-)-vesamicol hydrochloride
MFCD00055231 |
| Description | (±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. (±)-Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 2 nM (Vesicular acetylcholine transport), 26 nM (σ1 receptors) and 34 nM (σ2 receptors)[1] |
| In Vitro | The pharmacological actions of (±)-Vesamicol have been attributed to inhibition of acetylcholine transport into synaptic vesicles and the subsequent quantal release of acetylcholine[1]. |
| In Vivo | (±)-Vesamicol (3 mg/kg; intraperitoneal injection; once; male Wistar rats) treatment increases the levels of cytosolic acetylcholine (ACh) in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum[2]. Animal Model: Male Wistar rats (120-300 g)[2] Dosage: 3 mg/kg Administration: Intraperitoneal injection; once Result: The levels of cytosolic acetylcholine (ACh) increased in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum. |
| References |
| Boiling Point | 393.5ºC at 760mmHg |
|---|---|
| Molecular Formula | C17H26ClNO |
| Molecular Weight | 295.84700 |
| Flash Point | 97ºC |
| Exact Mass | 295.17000 |
| PSA | 23.47000 |
| LogP | 3.90940 |
| Vapour Pressure | 6.73E-07mmHg at 25°C |
| WGK Germany | 3 |
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