37762-06-4

37762-06-4 structure

Name: Zaprinast
Chemical Name: zaprinast
CAS Number: 37762-06-4
Molecular Formula: C₁₃H₁₃N₅O₂
Molecular Weight: 271.275
Catalog: API Antiallergic Allergic reaction medium blocker
Create Date: 2018-12-29 19:33:48
Modify Date: 2024-01-02 19:11:34
Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs)[1]. Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately[2]. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects[3].

Name	zaprinast
Synonyms	1H-1,2,3-triazolo[4,5-d]pyrimidin-7-ol, 5-(2-propoxyphenyl)- 2-(2-PROPYLOXYPHENYL)-8-AZAPURIN-6-ONE 5-(2-Propoxyphenyl)-1,4-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 2-o-propoxyphenyl-8-azapurin-6-one EINECS 253-655-1 Potassium phosphate monobasic Zaprinast 3,6-dihydro-5-(2-propoxyphenyl) Phenylaza purinon 2-(2-Propoxyphenyl)-8-azahypoxanthine MFCD00214073 5-(2-Propoxyphenyl)-2,3-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one, 3,4-dihydro-5-(2-propoxyphenyl)- B 22,948 8-Aza-2-(2-propoxyphenyl)-6-purinone 5-(2-propoxyphenyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one, 1,4-dihydro-5-(2-propoxyphenyl)- 5-(2-Propoxyphenyl)-3,4-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one 1,4-Dihydro-5-(2-propoxyphenyl)-1,2,3-triazolo[4,5-d]pyrimidin-7-one 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one, 2,3-dihydro-5-(2-propoxyphenyl)-

Description	Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs)[1]. Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately[2]. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects[3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Immunology/Inflammation >> CXCR Research Areas >> Neurological Disease
Target	PDE[1], GPR35[2]
References	[1]. Choi SH , et al. Zaprinast, an inhibitor of cGMP-selective phosphodiesterases, enhances the secretion of TNF-alpha and IL-1beta and the expression of iNOS and MHC class II molecules in rat microglial cells. J Neurosci Res. 2002 Feb 1;67(3):411-21. [2]. Taniguchi Y, et al. Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Lett. 2006 Sep 18;580(21):5003-8. Epub 2006 Aug 17. [3]. Keswani AN , et al The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through antiproliferative and proapoptotic effects. J Cardiovasc Pharmacol Ther. 2009 Jun;14(2):116-24.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26;S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	XZ6157358