191338-87-1

191338-87-1 structure

Name: Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid)
Chemical Name: ac-esmd-cho
CAS Number: 191338-87-1
Molecular Formula: C₁₉H₃₀N₄O₁₀S
Molecular Weight: 506.527
Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
Create Date: 2018-12-13 10:11:14
Modify Date: 2025-08-30 21:40:54
Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site[1][2].

Name	ac-esmd-cho
Synonyms	ACETYL-GLU-SER-MET-ASPARTINAL AC-ESMD-ALDEHYDE N-ACETYL-GLU-SER-MET-ASPARTINAL AC-GLU-SER-MET-ASP-CHO L-Methioninamide, N-acetyl-L-α-glutamyl-L-seryl-N-[(1S)-2-carboxy-1-formylethyl]- Acetyl-glutamyl-serinyl-methionyl-aspartal N-Acetyl-L-α-glutamyl-L-seryl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-methioninamide AC-GLU-SER-MET-ASP-ALDEHYDE

Description	Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase
References	[1]. Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50. [2]. Agniswamy J, et al. Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J. 2007 Sep;274(18):4752-65.

WGK Germany	3