636-54-4

636-54-4 structure

Name: Clopamide
Chemical Name: Clopamide
CAS Number: 636-54-4
Molecular Formula: C₁₄H₂₀ClN₃O₃S
Molecular Weight: 345.845
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2018-09-16 09:04:29
Modify Date: 2025-08-25 13:49:43
Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research[1][2].

Name	Clopamide
Synonyms	EINECS 211-261-7 Brinaldix DT-327 4-Chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)-, cis- CLOPAMIDUM ChlosudiMepriMyl Adurix MFCD00941495 4-Chloro-N-(2,6-dimethylpiperidino)-3-sulfamoylbenzamide 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethylpiperidin-1-yl)benzamide Aquex 4-Chloro-N-(2,6-dimethylpiperidin-1-yl)-3-sulfamoylbenzamide Benzamide, 3-(aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]- Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)- 4-Chloro-N-(2,6-dimethyl-1-piperidinyl)-3-sulfamoylbenzamide

Description	Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Clopamide is actively secreted by renal tubular cells and the True Tubular Excretion Fraction (TTEF) value is 10%[3].
In Vivo	The venoconstrictor response to bradykinin is attenuated after oral administration of Clopamide (0.5 mg/kg), and by concomitant local infusion of cyclosporine-A (1-10 μg/min) in conscious dogs[4].
References	[1]. J J McNeil, et al. Clopamide: plasma concentrations and diuretic effect in humans. Clin Pharmacol Ther. 1987 Sep;42(3):299-304. [2]. Yoshiteru Noutoshi, et al. Diuretics prime plant immunity in Arabidopsis thaliana. PLoS One. 2012;7(10):e48443. [3]. B Odlind, et al. Renal tubular secretion and effects of chlorothiazide, hydrochlorothiazide and clopamide: a study in the avian kidney. Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):187-97. [4]. E Müller-Schweinitzer, et al. Interaction of cyclosporine-A with the renin-angiotensin system in canine veins. Naunyn Schmiedebergs Arch Pharmacol. 1989 Aug;340(2):252-7.

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H317-H334
Precautionary Statements	P261-P280-P284-P304 + P340-P342 + P311
Hazard Codes	Xn
Risk Phrases	R42/43
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%