127-58-2

127-58-2 structure

Name: sulfamerazine sodium
Chemical Name: sodium,(4-aminophenyl)sulfonyl-(4-methylpyrimidin-2-yl)azanide
CAS Number: 127-58-2
Molecular Formula: C₁₁H₁₁N₄NaO₂S
Molecular Weight: 286.285
Catalog: API Synthetic anti-infective drugs Sulfonamides and synergists
Create Date: 2018-07-23 10:56:05
Modify Date: 2024-01-04 14:40:57
Sulfamerazine Sodium is a sulfonamide antibacterial.Target: AntibacterialSulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamerazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA [1].

Name	sodium,(4-aminophenyl)sulfonyl-(4-methylpyrimidin-2-yl)azanide
Synonyms	EINECS 204-851-0 Sulfamerazin natrium Benzenesulfonamide, 4-amino-N-(4-methyl-2-pyrimidinyl)-, sodium salt (1:1) MFCD00068332 Sodium [(4-aminophenyl)sulfonyl](4-methyl-2-pyrimidinyl)azanide 2-Sulfanilamido-4-methylpyrimidine sodium salt Solumedine UNII-JOV4UJY07O Solfamerazina sodica [DCIT] Sodium sulfamerazine sulfamerazine sodium Soluble sulfamerazine Sodium sulphamerazine Sodium [(4-aminophenyl)sulfonyl](4-methylpyrimidin-2-yl)azanide Sulfamerazine sodium salt Sulfamerazine (sodium salt)

Description	Sulfamerazine Sodium is a sulfonamide antibacterial.Target: AntibacterialSulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamerazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA [1].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. HALL, W.H. and W.W. SPINK, Sulfamerazine: clinical evaluation in 116 cases. Journal of the American Medical Association, 1943. 123(3): p. 125-131.

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(4-methyl-2-pyrimidinyl)-, monosodium salt

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H332
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/22
Safety Phrases	S7-S24-S45
RIDADR	NONH for all modes of transport
WGK Germany	3