3811-73-2

3811-73-2 structure

Name: 2-Mercaptopyridine N-oxide sodium
Chemical Name: Sodium omadine
CAS Number: 3811-73-2
Molecular Formula: C₅H₄NNaOS
Molecular Weight: 149.146
Catalog: Organic raw materials Organometallic salt
Create Date: 2018-08-02 00:50:57
Modify Date: 2024-01-01 22:40:30
2-Mercaptopyridine N-oxide sodium has bactericidal effect and is against a standard strain of Mycobacterium tuberculosis H37Rv (ATCC 27294) with MIC90 of 7.20 μM. 2-Mercaptopyridine N-oxide sodium and its complex with iron, gallium, and bismuth have good anti-M. tuberculosis activity. 2-Mercaptopyridine N-oxide sodium has potential for the treatment of tuberculosis[1].

Name	Sodium omadine
Synonyms	Sodium Pyrithione 1-Hydroxy-2-pyridinethione sodium salt MFCD01941547 2-Mercaptopyridine-1-oxide sodium salt Pyrithione sodium salt 1-hydroxy-2(1H)-pyridinethione sodium salt Sodi Sodium 2-pyridinethiolate 1-oxide Sodium pyridine-2-thiolate 1-oxide 1-hydroxy-1,2-dihydropyridine-2-thione sodium salt 2-Mercaptopyridine-N-Oxide,Sodium Salt 1-hydroxy-1H-pyridine-2-thione sodium salt NaPT 2-Pyridinethiol-1-oxide sodium salt Sodium-2-pyridinethiol-1-oxide Sodium pyrithione(NaPT) 2-Pyridinethiol, 1-oxide, sodium salt (1:1) N-Hydroxypyridinethione Sodium Salt thione(reagent) 2-Mercaptopyridine N-Oxide Sodium Salt EINECS 223-296-5 PYRITHIONE SODIUM Sodium pyrithion

Description	2-Mercaptopyridine N-oxide sodium has bactericidal effect and is against a standard strain of Mycobacterium tuberculosis H37Rv (ATCC 27294) with MIC90 of 7.20 μM. 2-Mercaptopyridine N-oxide sodium and its complex with iron, gallium, and bismuth have good anti-M. tuberculosis activity. 2-Mercaptopyridine N-oxide sodium has potential for the treatment of tuberculosis[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Debora L Campos, et al. Bactericidal Effect of pyridine-2-thiol 1-oxide Sodium Salt and Its Complex With Iron Against Resistant Clinical Isolates of Mycobacterium Tuberculosis. J Antibiot (Tokyo). 2020 Feb;73(2):120-124.

Density	1.22
Boiling Point	109 °C
Melting Point	-25 °C
Molecular Formula	C₅H₄NNaOS
Molecular Weight	149.146
Flash Point	107.3ºC
Exact Mass	148.991135
PSA	25.46000
LogP	1.02090
Water Solubility	54.7 g/100 mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT9000000

CHEMICAL NAME :: 2-Pyridinethiol, N-oxide, sodium salt

CAS REGISTRY NUMBER :: 3811-73-2

LAST UPDATED :: 199712

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C5-H5-N-O-S.Na

MOLECULAR WEIGHT :: 150.16

WISWESSER LINE NOTATION :: T6NJ AO BS &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,883,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,883,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 428 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,883,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04703

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,693,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9403 No. of Facilities: 1876 (estimated) No. of Industries: 40 No. of Occupations: 42 No. of Employees: 69571 (estimated) No. of Female Employees: 7591 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/38
Safety Phrases	S26-S36-S24/25-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UT9000000
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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