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673-31-4

673-31-4 structure

673-31-4 structure

Name: phenprobamate
Chemical Name: 3-phenylpropyl carbamate
CAS Number: 673-31-4
Molecular Formula: C₁₀H₁₃NO₂
Molecular Weight: 179.216
Catalog: API Anesthetic Agents Skeletal muscle relaxant
Create Date: 2018-06-20 21:37:28
Modify Date: 2024-01-01 21:05:00
Phenprobamate (3-Phenylpropyl carbamate; MH 532; Proformiphen) is a widely used, centrally acting skeletal muscle relaxant, with sedative and anticonvulsant effects[1].

Name	3-phenylpropyl carbamate
Synonyms	Quamaquil Extacol Proformiphen Carbamic Acid 3-Phenylpropyl Ester phenprobamate Nelaxan 3-Phenylpropyl carbamate Gamaquil EINECS 211-606-1 MFCD00868163 Methanol, 1-imino-1-(3-phenylpropoxy)- Eirenal benzenepropanol g-Phenylpropyl Carbamate 3-Phenylpropyl hydrogen carbonimidate Palmita Ansepron Benzenepropanol, carbamate Actiphan Actozine

Description	Phenprobamate (3-Phenylpropyl carbamate; MH 532; Proformiphen) is a widely used, centrally acting skeletal muscle relaxant, with sedative and anticonvulsant effects[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. J X Sun, et al. High-performance liquid chromatographic analysis, plasma protein binding and red blood cell partitioning of phenprobamate. Biopharm Drug Dispos. Jul-Aug 1987;8(4):341-51.

Density	1.1±0.1 g/cm3
Boiling Point	295.5±33.0 °C at 760 mmHg
Melting Point	101-104℃
Molecular Formula	C₁₀H₁₃NO₂
Molecular Weight	179.216
Flash Point	132.5±25.4 °C
Exact Mass	179.094635
PSA	52.32000
LogP	2.16
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.519

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB9275000

CHEMICAL NAME :: 1-Propanol, 3-phenyl-, carbamate

CAS REGISTRY NUMBER :: 673-31-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C10-H13-N-O2

MOLECULAR WEIGHT :: 179.24

WISWESSER LINE NOTATION :: ZVO3R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1110 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,856,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,140,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,340,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH. Volume(issue)/page/year: 10,1047,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,402,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 285 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,402,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 930 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,143,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 510 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,143,1959

HS Code	2924299090

122-97-4 structure

122-97-4

622-46-8 structure

622-46-8

~96%

673-31-4 structure

673-31-4

Literature: Ichikawa, Yoshiyasu; Morishita, Yukinori; Kusaba, Shuhei; Sakiyama, Naoto; Matsuda, Yasunori; Nakano, Keiji; Kotsuki, Hiyoshizo Synlett, 2010 , # 12 p. 1815 - 1818

122-97-4 structure

122-97-4

~%

673-31-4 structure

673-31-4

Literature: European Journal of Organic Chemistry, , # 5 p. 908 - 911

122-97-4 structure

122-97-4

143-33-9 structure

143-33-9

~%

673-31-4 structure

673-31-4

Literature: Chemical and Pharmaceutical Bulletin, , vol. 33, # 6 p. 2403 - 2410

Precursor 3
122-97-4 622-46-8 143-33-9
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%