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673-31-4生产厂家

673-31-4价格

673-31-4

673-31-4结构式
673-31-4结构式
  • 常用中文名:苯丙氨酯
  • 常用英文名:phenprobamate
  • CAS号:673-31-4
  • 分子式:C10H13NO2
  • 分子量:179.216
  • 相关类别: 原料药 Anesthetic Agents 骨骼肌松弛药
  • 发布时间:2018-06-20 21:37:28
  • 更新时间:2024-01-01 21:05:00
  • 苯丙氨酯(3-苯基丙基氨基甲酸酯;MH 532;普罗福米芬)是一种广泛使用的中枢作用骨骼肌松弛剂,具有镇静和抗惊厥作用[1]。

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中文名 苯丙氨酯
英文名 3-phenylpropyl carbamate
中文别名 3-苯基-1-丙醇氨基甲酸酯
苯丙氨酸
英文别名 Quamaquil
Extacol
Proformiphen
Carbamic Acid 3-Phenylpropyl Ester
phenprobamate
Nelaxan
3-Phenylpropyl carbamate
Gamaquil
EINECS 211-606-1
MFCD00868163
Methanol, 1-imino-1-(3-phenylpropoxy)-
Eirenal
benzenepropanol
g-Phenylpropyl Carbamate
3-Phenylpropyl hydrogen carbonimidate
Palmita
Ansepron
Benzenepropanol, carbamate
Actiphan
Actozine
描述 苯丙氨酯(3-苯基丙基氨基甲酸酯;MH 532;普罗福米芬)是一种广泛使用的中枢作用骨骼肌松弛剂,具有镇静和抗惊厥作用[1]。
相关类别
参考文献

[1]. J X Sun, et al. High-performance liquid chromatographic analysis, plasma protein binding and red blood cell partitioning of phenprobamate. Biopharm Drug Dispos. Jul-Aug 1987;8(4):341-51.

密度 1.1±0.1 g/cm3
沸点 295.5±33.0 °C at 760 mmHg
熔点 101-104℃
分子式 C10H13NO2
分子量 179.216
闪点 132.5±25.4 °C
精确质量 179.094635
PSA 52.32000
LogP 2.16
蒸汽压 0.0±0.7 mmHg at 25°C
折射率 1.519
储存条件 室温
计算化学

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:1

3.氢键受体数量:2

4.可旋转化学键数量:5

5.互变异构体数量:2

6.拓扑分子极性表面积:52.3

7.重原子数量:13

8.表面电荷:0

9.复杂度:153

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UB9275000
CHEMICAL NAME :
1-Propanol, 3-phenyl-, carbamate
CAS REGISTRY NUMBER :
673-31-4
LAST UPDATED :
199612
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C10-H13-N-O2
MOLECULAR WEIGHT :
179.24
WISWESSER LINE NOTATION :
ZVO3R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1110 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,856,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
275 mg/kg
TOXIC EFFECTS :
Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,140,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
840 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,340,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH. Volume(issue)/page/year: 10,1047,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,402,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
285 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,402,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
930 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,143,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
510 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,143,1959

海关编码 2924299090
上游产品  3

下游产品  0

【方法一】
由3-苯丙醇与氰酸钠缩合、水解而得。将无水甲苯、3-苯丙醇及氰酸钠加入反应罐中,冷至10℃,搅拌下导入氯化氢气体,约80min,温度上升至55℃后开始下降。通气毕,在55-60℃反应0.5h。冷至30℃,加入氨水升温至70℃,静置0.5h,分取有机层,过滤,滤液冷却结晶。过滤,结晶用甲苯洗涤,再用蒸馏水洗至氯根符合要求止。气流干燥,得苯丙氨酯。
海关编码 2924299090
中文概述 2924299090. 其他环酰胺(包括环氨基甲酸酯)(包括其衍生物以及他们的盐). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素 品名, 成分含量, 用途, 包装
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%