1246529-32-7
1246529-32-7 structure
- Name: MPI-0479605
- Chemical Name: 9H-Purine-2,6-diamine, N6-cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-
- CAS Number: 1246529-32-7
- Molecular Formula: C22H29N7O
- Molecular Weight: 407.512
- Catalog: Biochemical Inhibitor Cytoskeletal Signaling Kinesin inhibitor
- Create Date: 2018-12-11 09:15:04
- Modify Date: 2024-01-02 16:48:05
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MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM.
| Name | 9H-Purine-2,6-diamine, N6-cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]- |
|---|---|
| Synonyms |
N-Cyclohexyl-N-[2-methyl-4-(4-morpholinyl)phenyl]-3H-purine-2,6-diamine
mpi-0479605 9H-Purine-2,6-diamine, N-cyclohexyl-N-[2-methyl-4-(4-morpholinyl)phenyl]- |
| Description | MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM. |
|---|---|
| Related Catalog | |
| Target |
Mps1:1.8 nM (IC50) ALK:0.26 μM (IC50) B-RAF:3.2 μM (IC50) ERK2:3.9 μM (IC50) FAK1:2.7 μM (IC50) FER:0.59 μM (IC50) FLT3:0.08 μM (IC50) INSR:0.38 μM (IC50) JNK1:0.11 μM (IC50) PLK4:3.3 μM (IC50) STK33:1.1 μM (IC50) |
| In Vitro | MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM. MPI-0479605 (0.1-10 μM) reduces cell viability of HCT-116 cells in a dose-dependent manner. MPI-0479605 shows severe defects in the ability to align chromosomes at the metaphase plate, but causes complete cytokinesis[1]. |
| In Vivo | MPI-0479605 (30 mg/kg daily or 150 mg/kg every fourth day (Q4D), i.p.) inhibits tumor growth by 49% and 74 % in HCT-116 xenografts. However, MPI-0479605 does not show inhibitory activity via daily dosing on the Colo-205 xenografts, and dosing every four days causes 63% tumor growth inhibition (TGI)[1]. |
| Animal Admin | HCT-116 or Colo-205 cells are transplanted subcutaneously into the flanks of nude (nu+/nu+) mice and compound (MPI-0479605) treatment is initiated when tumor masses reaches an average size of 100 mm3. MPI-0479605 is formulated in 5% dimethylacetamide (DMA)/12% ethanol/40% PEG-300, ispinesib is formulated in 2% cremaphor/2% DMA, and 5-fluorouracil is formulated in 2% sodium bicarbonate. Tumor volume is measured using vernier calipers and tumor growth inhibition (TGI) is calculated as: %TGI= 100-100(change in median tumor volume of treated)/(change in median tumor volume control)[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C22H29N7O |
| Molecular Weight | 407.512 |
| Exact Mass | 407.243347 |
| PSA | 90.99000 |
| LogP | 1.69 |
| Index of Refraction | 1.700 |
| Storage condition | -20℃ |