Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
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Purity: 98.0%
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1203680-76-5

1203680-76-5 structure

Name: AS1949490
Chemical Name: 3-[(4-Chlorobenzyl)oxy]-N-[(1S)-1-phenylethyl]-2-thiophenecarboxa mide
CAS Number: 1203680-76-5
Molecular Formula: C₂₀H₁₈ClNO₂S
Molecular Weight: 371.88
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2016-10-04 15:16:45
Modify Date: 2025-08-25 15:02:02
AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5′ phosphatase 2) inhibitor, with an IC50 of 620 nM. AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2].

Name	3-[(4-Chlorobenzyl)oxy]-N-[(1S)-1-phenylethyl]-2-thiophenecarboxa mide
Synonyms	3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]- 2-thiophenecarboxamide AS 1949490

Description	AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5′ phosphatase 2) inhibitor, with an IC50 of 620 nM. AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Metabolic Disease
Target	IC50: 620 nM (SHIP-2)[1].
References	[1]. Suwa A, et al. Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br J Pharmacol. 2009 Oct;158(3):879-87. [2]. Suwa A, et al. Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes. Eur J Pharmacol. 2010 Sep 10;642(1-3):177-82.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
RIDADR	NONH for all modes of transport