115850-11-8
115850-11-8 structure
- Name: sodium,(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,pentahydrate
- Chemical Name: sodium,(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,pentahydrate
- CAS Number: 115850-11-8
- Molecular Formula: C14H23N8NaO9S3
- Molecular Weight: 566.56500
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2016-12-20 07:56:01
- Modify Date: 2024-02-17 21:23:08
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Cefazolin sodium pentahydrate is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin sodium pentahydrate has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[2].
| Name | sodium,(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,pentahydrate |
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| Synonyms |
UNII-XLJ4VSY381
Cefazolin sodium hydrate (JP16) 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-,sodium salt,hydrate (1:1:5),(6R,7R) |
| Description | Cefazolin sodium pentahydrate is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin sodium pentahydrate has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[2]. |
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| Related Catalog | |
| In Vitro | Cefazolin sodium pentahydrate (0-300 μg/ml; 6 or 24 h) has a direct anti-inflammatory effect on C8-B4 cells stimulated by lipopolysaccharide[2]. Cefazolin sodium pentahydrate (0-400 μM; 72 h) treatment inhibits IL-2, IL-4 and IL-15-induced cell proliferation[3]. Cefazolin sodium pentahydrate (0-400 μM; 30 min) treatment inhibits IL-2, IL-4, IL-15 and IL-21-stimulated JAK3 phosphorylation[3]. Cell Viability Assay[2] Cell Line: C8-B4 cells Concentration: 0, 50, 100, 150, 200, 250, or 300 μg/ml Incubation Time: 6 or 24 hours Result: Inhibited the increase of IL-1β at all doses, but inhibited the increase of IL-6 only at 200 μg/ml. Cell Proliferation Assay[3] Cell Line: PBMC, and TF-1 cells Concentration: 0, 100, 200, and 400 μM Incubation Time: 72 hours Result: Reduced IL-2, IL-4 and IL-15-induced cell proliferation, suggested that Cefazolin interferes not only with IL-15Rα, but also with IL-2/IL-15Rβ and/or γc. Western Blot Analysis[3] Cell Line: PBMC, NK-92, and TF-1 cells Concentration: 0, 100, 200, and 400 μM Incubation Time: 30 min Result: Diminished the phosphorylation of JAK3 in response to the cytokine treatment, concluded suppressing signal transduction by γc receptors. |
| In Vivo | Cefazolin sodium pentahydrate (Subcutaneous injection; 300-500 mg/kg; once daily; 5 d) treatment improves learning and memory in mice after surgery[2]. Animal Model: 6- to 8-week-old male CD-1 mice underwent clinical exploratory laparotomy[2] Dosage: 300-500 mg/kg Administration: Subcutaneous injection; 300-500 mg/kg; once daily; 5 days Result: Attenuated learning and memory dysfunction induced by the surgery. |
| References |
[1]. R Quintiliani, et al. Cefazolin. Ann Intern Med. 1978 Nov;89(5 Pt 1):650-6. |
| Molecular Formula | C14H23N8NaO9S3 |
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| Molecular Weight | 566.56500 |
| Exact Mass | 566.06500 |
| PSA | 287.40000 |