55266-18-7
55266-18-7 structure
- Name: MnTBAP chloride
- Chemical Name: Chloro[4,4',4'',4'''-(5,10,15,20-porphyrintetrayl-κ2N21,N23)tetrabenzoato(2-)]manganese
- CAS Number: 55266-18-7
- Molecular Formula: C48H28ClMnN4O8
- Molecular Weight: 879.14900
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2016-11-22 00:39:31
- Modify Date: 2025-08-25 17:09:17
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MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research[1][2].
| Name | Chloro[4,4',4'',4'''-(5,10,15,20-porphyrintetrayl-κ2N21,N23)tetrabenzoato(2-)]manganese |
|---|---|
| Synonyms | MFCD06227760 |
| Description | MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research[1][2]. |
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| Related Catalog | |
| Target |
NFκB |
| In Vitro | MnTBAP chloride (pretreated 1.14 μM before TGF-β1 of 10 ng/mL) partially but significantly restores E-cadherin reduction and suppresses the induction of α-SMA and vimentin in immortalized mouse proximal tubular cells (mPTCs)[1]. MnTBAP chloride (50 μM; 6 hours) increases BMPR-II mRNA by 1.3-fold at 2 h, but does not affect protein expression of BMPR-II during a time course of 16 h in HUVECs. MnTBAP chloride increases phosphorylation of Smad 1/5, suggesting modulation of the BMP signaling pathway[2]. |
| In Vivo | MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice[1]. Animal Model: C57BL/6J mice with 5/6 nephrectomy (Nx)[1] Dosage: 10 mg/kg Administration: IP; three times per week for twelve weeks Result: Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys. |
| References |
| Molecular Formula | C48H28ClMnN4O8 |
|---|---|
| Molecular Weight | 879.14900 |
| Exact Mass | 878.09800 |
| PSA | 208.26000 |
| LogP | 3.42070 |
| Storage condition | -20°C |
| Hazard Codes | Xi |
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