20298-86-6
20298-86-6 structure
- Name: phycocyanobilin
- Chemical Name: (3E)-phycocyanobilin
- CAS Number: 20298-86-6
- Molecular Formula: C33H38N4O6
- Molecular Weight: 586.67800
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-07-04 11:58:42
- Modify Date: 2024-01-03 14:24:19
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Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease[1][2][3].
| Name | (3E)-phycocyanobilin |
|---|---|
| Synonyms |
3-[(2Z,5E)-2-[[3-(2-carboxyethyl)-5-[(Z)-[(3E,4R)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-2-yl]methylidene]-5-[(4-ethyl-3-methyl-5-oxopyrrol-2-yl)methylidene]-4-methylpyrrol-3-yl]propanoic acid
phycocyanobilin 3,3'-(18-ethyl-3-ethylidene-2,7,13,17-tetramethyl-1,19-dioxo-1,2,3,19,22,24-hexahydro-21H-biline-8,12-diyl)-bis-propionic acid Phycobilin 21H-Biline-8,12-dipropanoic acid,18-ethyl-3-ethylidene-1,2,3,19,22,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-,(2R,3E) |
| Description | Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Phycocyanobilin (100 μM; 0-250 min) 抑制亚油酸甲酯的过氧化，并产生较长的诱导期[1]。 Phycocyanobilin (1 mM; 0-300 min) 抑制脂质体的氧化[1]。 |
| In Vivo | Phycocyanobilin (15 mg/kg; p.o.; in diet for 2 weeks) 在 2 型糖尿病小鼠中显示抗氧化作用[3]。 Animal Model: Male C57BL/Ks J db/db mice, a rodent model for type 2 diabetes[3] Dosage: 15 mg/kg Administration: In diet for 2 weeks Result: Significantly decreased blood glucose levels. Normalized the increases in urinary 8-OHdG and 8-epi-PGF2α levels, renal oxidative stress markers evaluated by renal 8-OHdG staining and DHE staining, Nox4 mRNA, and protein expression, as well as the mRNA levels of other NAD(P)H oxidase components, inflammatory markers and HO-1. |
| References |
| Density | 1.31±0.1 g/cm3 |
|---|---|
| Boiling Point | 892.1±65.0 °C |
| Molecular Formula | C33H38N4O6 |
| Molecular Weight | 586.67800 |
| Exact Mass | 586.27900 |
| PSA | 164.71000 |
| LogP | 3.12850 |
| Hazard Codes | Xi |
|---|---|
| HS Code | 3203001990 |
| HS Code | 3203001990 |
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