343630-41-1

343630-41-1 structure

Name: NS 3623
Chemical Name: 1-[4-Bromo-2-(1H-tetrazol-5-yl)phenyl]-3-[3-(trifluoromethyl)phen yl]ure
CAS Number: 343630-41-1
Molecular Formula: C₁₅H₁₀BrF₃N₆O
Molecular Weight: 427.17900
Create Date: 2016-02-06 19:57:57
Modify Date: 2024-01-07 18:03:13
NS3623 is a hERG (KV11.1) and KV4.3 channel activator. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect[1][2].

Name	1-[4-Bromo-2-(1H-tetrazol-5-yl)phenyl]-3-[3-(trifluoromethyl)phen yl]ure

Description	NS3623 is a hERG (KV11.1) and KV4.3 channel activator. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect[1][2].
References	[1]. Hansen RS, et al. In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig. J Cardiovasc Pharmacol. 2008 Jul;52(1):35-41. [2]. Diness JG, et al. Antiarrhythmic effect of IKr activation in a cellular model of LQT3. Heart Rhythm. 2009 Jan;6(1):100-6. [3]. Calloe K, et al. A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem Pharmacol. 2016 May 15;108:36-46.