57836-11-0

57836-11-0 structure

Name: H-Gly-Sar-Sar-OH
Chemical Name: h-gly-sar-sar-oh
CAS Number: 57836-11-0
Molecular Formula: C₈H₁₅N₃O₄
Molecular Weight: 217.22200
Catalog: Research Areas Others
Create Date: 2016-09-23 15:49:18
Modify Date: 2024-01-16 19:29:45
H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation[1][2][3].

Name	h-gly-sar-sar-oh

Description	H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation[1][2][3].
Related Catalog	Research Areas >> Others
In Vivo	H-Gly-Sar-Sar-OH (0.1 mM；灌注；单剂量) 在 Sprague-Dawley 大鼠肾脏中未显著被水解 (给药 60 min) 或清除[2]。 H-Gly-Sar-Sar-OH (10 mg/kg；口服；单剂量) 在自发性高血压大鼠 (SHRs) 中显示出稳定性[3]。 H-Gly-Sar-Sar-OH 在自发性高血压大鼠中的药代动力学 (PK) 参数[3] Week old Cmax (nmol/mL, plasma) Tmax (min) AUC0-90 min (nmol•min/mL, plasma) T1/2 (min) 8 4.6±0.6 30 258.0±32.1 75 40 10.7±1.5 30 621.0±86.3 83 Animal Model: Male Sprague-Dawley rats (350 g)[2]. Dosage: 0.1 mM. Administration: Perfusion (kidney); single dose. Result: Showed stability. Animal Model: Male SHRs (8 and 40 week-old)[3]. Dosage: 10 mg/kg. Administration: Oral gavage; single dose. Result: Detected in full form.
References	[1]. Hong SM, et al. Structural Design of Oligopeptides for Intestinal Transport Model. J Agric Food Chem. 2016 Mar 16;64(10):2072-9. [2]. Minami H, et al. Oligopeptides: mechanism of renal clearance depends on molecular structure. Am J Physiol. 1992 Jul;263(1 Pt 2):F109-15. [3]. Hanh VT, et al. Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats. J Agric Food Chem. 2017 Jul 26;65(29):5935-5943.