54739-19-4

54739-19-4 structure

Name: Clovoxamine fumarate
Chemical Name: clovoxamine
CAS Number: 54739-19-4
Molecular Formula: C₁₄H₂₁ClN₂O₂
Molecular Weight: 284.78200
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-02-27 08:00:00
Modify Date: 2024-01-06 16:09:53
Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant[1][2][3].

Name	clovoxamine
Synonyms	2-[(E)-[1-(4-chlorophenyl)-5-methoxypentylidene]amino]oxyethanamine Clovoxamine Clovoxaminum [INN-Latin] p-Chloro-5-methoxyvalerophenone (E)-O-(2-aminoethyl)oxime (E)-1-(4-Chlorophenyl)-5-methoxy-1-pentanone O-(2-aminoethyl)oxime Clovoxamina [Spanish] 4'-Chloro-5-methoxyvalerophenone (E)-O-(2-aminoethyl)oxime clovoxaminum 1-Pentanone,1-(4-chlorophenyl)-5-methoxy-,O-(2-aminoethyl)oxime,(E) Clovoxamina [INN-Spanish]

Description	Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant[1][2][3].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Staroń J, et al. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine. Eur J Med Chem. 2021 Aug 5;220:113533. [2]. Saletu B, et al. Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man. J Neural Transm. 1980;49(1-2):63-86. [3]. de Jong GJ. The use of a pre-column for the direct high-performance liquid chromatographic determination of the anti-depressants clovoxamine and fluvoxamine in plasma. J Chromatogr. 1980 Aug 8;183(2):203-11.

CHEMICAL NAME :: 1-Pentanone, 1-(4-chlorophenyl)-5-methoxy-, O-(2-aminoethyl)oxime, (E)-

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,563,1979

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,563,1979

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,563,1979