3371-85-5

3371-85-5 structure

Name: Voacamine
Chemical Name: methyl 12-methoxy-13-(17-methoxy-17-oxovobasan-3alpha-yl)ibogamine-18-carboxylate
CAS Number: 3371-85-5
Molecular Formula: C₄₃H₅₂N₄O₅
Molecular Weight: 704.89700
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2016-07-26 11:39:26
Modify Date: 2024-01-02 11:31:31
Voacamine, an indole alkaloid, isolated from Voacanga Africana, exhibits potent cannabinoid CB1 receptor antagonistic activity[1]. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells[1].

Name	methyl 12-methoxy-13-(17-methoxy-17-oxovobasan-3alpha-yl)ibogamine-18-carboxylate
Synonyms	Dodecandisaeure-monomethylester methyl hydrogen dodecanedioate monomethyl-dodecanedioate epi-Voacamin methyl ester of 1,12-dodecanedioic acid,dimethyl ester Dodecanedioic acid monomethyl ester 11MeOCO undec acid Voacamine

Description	Voacamine, an indole alkaloid, isolated from Voacanga Africana, exhibits potent cannabinoid CB1 receptor antagonistic activity[1]. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
References	[1]. Kitajima M, et al. Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4. [2]. Meschini S, et al. Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. Int J Oncol. 2005 Dec;27(6):1597-603.